Diisopropylethylamine → HCID 11082969, compound

Participants

Reaction Steps

In analogy with Example 2, 0.42 ml of Hünig's base is added to 0.193 g (1.1 mmol) of N-methoxycarbonyl-(L)-valine and 0.327 g (1.1 mmol) of TPTU in 3 ml of DMF and the whole is stirred at RT for 10 min. After that, 0.63 g (1 mmol) of 1-[p-(N,N-diethylamino)-phenyl]-4(S)-hydroxy-2-amino-5(S)-[N-(N-methoxycarbonyl-(L)-tert-leucyl)amino]-6-phenyl-2-azahexane hydrochloride (Example 2f), dissolved in 2 ml of DMF, is added and the mixture is stirred at RT for 21 h. After working-up in the same way as described for Example 2, the residue is digested in DIPE and the title compound is filtered off. The suction filter residue is washed once again with DIPE and dried in a heated desiccator at 45° C. TLC: Rf0.50 (ethyl acetate). HPLC20-100: tret=10.93; FAB MS (M+H)+=685.

Provenance & Evidence