Diisopropylethylamine → HCID 23382096, compound

Participants

Reaction Steps

In analogy with Example 2e, 1.5 ml of Hünig's base are added to 0.77 g (4.3 mmol) of N-methoxycarbonyl-(L)-valine and 1.3 g (4.3 mmol) of TPTU in 20 ml of DMF and the whole is stirred at RT for 5 min. After that, 2.0 g (4.3 mmol) of 1-[p-(N,N-diethylamino)phenyl]-4(S)-hydroxy-2-(tert-butyloxycarbonyl)amino-5(S)-amino-6-phenyl-2-azahexane (Example 2d), dissolved in DMF, are added and the mixture is stirred at RT for 2 h. After working up in the same manner as described for Example 2e, the residue is digested in DIPE and the title compound is filtered off. The suction filter residue is washed once again with DIPE and dried in a heated desiccator at 60° C., with the title compound thereby being obtained. TLC: Rf=0.80 (methylene chloride/methanol). HPLC20-100: tret=11.79.

Provenance & Evidence