Potassium Carbonate → 4-(4-Methylpiperazin-1-yl)benzaldehyde

Participants

Reaction Conditions

Reaction Steps

20 ml (0.18 mol) of 1-methylpiperazine and 19 ml (0.18 mol) of 4-fluorobenzaldehyde (Fluka, Buchs, Switzerland), in each case in 45 ml of DMSO, are added to 25 g (0.18 mol) of K2CO3 in 90 ml of DMSO and the whole is stirred at 100° C. for 3 h. The reaction mixture is cooled down and poured onto 2l of ice water; this mixture is then extracted twice with ethyl acetate. The organic phases are washed with brine, dried (Na2SO4) and concentrated by evaporation, with the title compound thereby being obtained:

Provenance & Evidence