1,2-Dichloroethane → HCID 23382062, compound

Participants

Reaction Steps

129 mg (0.68 mmol) of N-methoxycarbonyl-(L)-tert-leucine, 244 mg (1.28 mmol) of EDC and 115 mg (0.85 mmol) of HOBT are initially introduced, under a N2 atmosphere, in 5.4 ml of DMF. After 20 min at RT, 0.355 ml (2.55 mmol) of triethylamine is added. 232 mg (0.425 mmol) of 1-[p-(4-methylpiperazin-1-yl)phenyl]-4(S)-hydroxy-2-amino-5(S)-[N-(N-methoxycarbonyl-(L)-valyl)amino]-6-phenyl-2-azahexane (Example 16g) are then added and the mixture is thoroughly stirred overnight; working-up then takes place in analogy with Example 16. Column chromatography (SiO2; ethyl acetate/ethanol 1:1) results in the title compound:

Provenance & Evidence