Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 54274056 | HCID 54274056 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54218971 | HCID 54218971 | 76% |
Reaction Steps
The compound (19-a)(0.288 g) was dissolved in the solvent mixture (acetic acid:water:THF=4:2:1)(30 ml), and the solution was maintained at 45° C. for 3.5 hours. The crude product obtained by the conventional treatment of the reaction mixture was purified on silica gel column to give the titled compound (20-a) [yield:0.184 g(76%)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06452039B1 |
|---|
| Source dataset | uspto-grants-2002_09 |
|---|
| ORD ID | ord-98145c7c3ae046bf8fcf94214b9cb959 |
|---|
| Source note | uspto-grants-2002_09 |
|---|
