Water → Chlorthal

HRID 1281222Notes

Reaction equation

HRID 1281222 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9](N)=[O:10])[C:5]([Cl:12])=[C:4]([Cl:13])[C:3]=1[C:14](N)=[O:15].[OH2:17].S(=O)(=O)(O)[OH:19]>>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([C:9]([OH:10])=[O:17])[C:5]([Cl:12])=[C:4]([Cl:13])[C:3]=1[C:14]([OH:15])=[O:19]

Participants

4

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 113240872,3,5,6-tetrachloro-1,4-benzenedicarboxamide2×

Product 1

HCID 16493Chlorthal

Procedure

In Examples 1 to 3, the hydrolysis of 2,3,5, 6-tetrachloro-1,4-benzenedicarboxamide occurred in sulfuric acid containing fuming sulfuric acid even in the absence of 2 mol, stoichiometric amount, of water added from outside per mol of 2,3,5,6-tetrachloro-1, 4-benzenedicarboxamide, and the reaction proceeded at 180° C. or lower temperatures, thereby forming desired 2,3,5,6-tetrachloro-1,4-benzenedicarboxylic acid.

Workup

  1. customproceeded at 180° C.

Sources & evidence

ORD record
ord-176fa8cb75734cefbc8f7d68ea8a1c9d
Source dataset
uspto-grants-2002_09
Patent number
US06452046B2

Reaction notes

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