HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-1,1,4,4,7-pentamethyl-1,2,3,4-tetrahydronaphthalene → (Z)-5-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(trimethylsilyl)vinyl]thiophene-2-ylmethyl Alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-1,1,4,4,7-pentamethyl-1,2,3,4-tetrahydronaphthalene | HCID 10039346 | — |
| Reactant | 5-[(Trimethylsilyl)ethynyl]thiophen-2-ylmethyl Tert-butyldiphenylsilyl Ether | HCID 22393094 | — |
| Product | (Z)-5-[2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(trimethylsilyl)vinyl]thiophene-2-ylmethyl Alcohol | HCID 23382405 | — |
Reaction Steps
Following General Procedure A, 5-[(trimethylsilyl)ethynyl]thiophen-2-ylmethyl tert-butyldiphenylsilyl Ether (Compound 13, 0.75 g, 1.8 mmol) and 2-bromo-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene (0.45 g, 1.67 mmol) were coupled to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06452032B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-3977f249f265455a853e2706509136b7 |
| Source note | uspto-grants-2002_09 |