4-[(trimethylsilyl)ethynyl]benzyl tert-butyldiphenylsilyl Ether → (Z)-4-{[8-(4-tert-Butylphenyl)-5,5-dimethyl-5,6-dihydronaphthalen-2-yl]-trimethylsilanylvinyl}benzyl Alcohol

Participants

Reaction Steps

Following General Procedure A, 4-[(trimethylsilyl)ethynyl]benzyl tert-butyldiphenylsilyl ether and 6-bromo-4-(tert-butylphenyl)-1,1-dimethyl-1,2-dihydronaphthalene (which can be prepared by the procedure described in Klein, et al., U.S. Pat. No. 5,952,345) were coupled to give the title compound (Compound 29). PNMR (300 MHz, CDCl3): δ0.0 (s, 9 H), 1.48 (s, 6 H), 1.51 (s, 9 H), 2.49 (d, J=4.8 Hz, 2 H), 4.82 (d, J=4.8 Hz, 2 H), 6.13 (t, J=4.8 Hz, 1 H), 7.00 (d, J=1.7 Hz, 1 H), 7.22 (dd, J=1.7, 7.9 Hz, 1 H), 7.30-7.50 (m, 8 H), 7.55 (d, J=8.8 Hz, H).

Provenance & Evidence