HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Sertraline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;2-hydroxy-2-phenylacetate | HCID 131718189 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Sertraline | HCID 68617 | — |
Reaction Steps
Sertraline base for use in the processes of the present invention may be produced by dissolving sertraline mandelate in ethyl acetate followed by neutralization of the sertraline mandelate with aqueous sodium hydroxide. The organic phase is separated from the aqueous phase and dried using magnesium sulfate. The solvent is removed under reduced pressure to produce sertraline base as an oil. Methods for making sertraline base are set forth in U.S. Pat. Nos. 4,536,518 and 5,248,699, the contents of which are incorporated herein by reference.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06452054B2 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-3687793606904e699c92ae1213a223dd |
| Source note | uspto-grants-2002_09 |