Hydrochloric Acid → 5-(2-pyrazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione dihydrochloride

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Reaction Steps

5-(2-pyrazinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (E67, 78 mg, 0.17 mmol) was dissolved in 2 ml of dioxane and then 4N HCl in dioxane solution (85 μl, 0.34 mmol) was added. The mixture was stirred at room temperature for 5 minutes, and then the solvent was removed in vacuum. The residue was triturated with petroleum ether to give 81.2 mg of the title compound as a yellow solid (90%, yield).

Provenance & Evidence