Pinacolone → HCID 86735615, compound

HRID 128140Notes

Reaction equation

HRID 128140 reaction equation
CC(C(C)(C)C)=O.[C:8]([C:12]([CH:14]=[O:15])=O)([CH3:11])([CH3:10])[CH3:9].CC(=[N:19][OH:20])C>>[C:8]([C:12](=[N:19][OH:20])[CH:14]=[O:15])([CH3:11])([CH3:10])[CH3:9]

Participants

4

Reactant 3

HCID 6416PinacoloneHCID 67180Acetone, oximeHCID 349972tert-Butylglyoxal2×

Product 1

HCID 86735615HCID 86735615, compound

Procedure

Yet another oxime intermediate is prepared from t-butyl methyl ketone, which is first transformed into t-butylglyoxal using the procedure of Fuson et al., J. Am. Chem. Soc. 61, 1938 (1939). The t-butylglyoxal, in aqueous solution at pH 4-5, is allowed to react with acetone oxime (commercially available) at about room temperature for about two days. The reaction product mixture is worked up by extracting it with ether, and the t-butylglyoxal oxime is isolated from the ether extract as colorless needles having a melting point of about 50°-52° C.

Workup

  1. extractionby extracting it with ether

Sources & evidence

ORD record
ord-569ebd4f04804b7cb77c7aa2a324e21b
Source dataset
uspto-grants-1981_03
Patent number
USRE030563

Reaction notes

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