Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → 4-(4-{2-[(2S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic Acid 4-fluoro-benzylamide

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane	HCID 12045564	—
Reactant	4-[4-(2-Aminoethyl)anilino]-N-(4-fluorobenzyl)-1-piperidinecarboxamide formate	HCID 69986724	—
Product	4-(4-{2-[(2S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic Acid 4-fluoro-benzylamide	HCID 10280301	40.4%

Reaction Steps

4-[4-(2-Aminoethyl)anilino]-N-(4-fluorobenzyl)-1-piperidinecarboxamide formate (0.77 g, 1.85 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.671 g, 1.66 mmol) according to Procedure G to give the title compound (0.53 g, 0.67 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06451814B1
Source dataset	uspto-grants-2002_09
ORD ID	ord-7e1c8fc8339b4d61bedefeae1c74900e
Source note	uspto-grants-2002_09