HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-[(2-allylphenoxy)methyl]oxirane → 4-(4-{2-[(2S)-3-(2-Allyl-phenoxy)-2-hydroxy-propylamino]-ethyl}-phenylamino)-piperidine-carboxylic acid octylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-[(2-allylphenoxy)methyl]oxirane | HCID 968915 | — |
| Reactant | 4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide formate | HCID 69987252 | — |
| Product | 4-(4-{2-[(2S)-3-(2-Allyl-phenoxy)-2-hydroxy-propylamino]-ethyl}-phenylamino)-piperidine-carboxylic acid octylamide | HCID 10144441 | 14% |
Reaction Steps
4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide formate (0.40 g, 0.95 mmol) was reacted with (2S)-2-[(2-allylphenoxy)methyl]oxirane (0.125 g, 0.713 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.060 g, 0.1 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06451814B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-a45cfb27adff49f4a57ee716af62bdb3 |
| Source note | uspto-grants-2002_09 |