Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10139202, compound

HRID 1281495Notes

Reaction equation

HRID 1281495 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:24]=[CH:23][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][CH3:22])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:42][C:43]1[CH:48]=[CH:47][C:46]([O:49][CH2:50][CH:51]2[CH2:53][O:52]2)=[CH:45][CH:44]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[CH2:21]([NH:20][C:18]([N:15]1[CH2:16][CH2:17][CH:12]([NH:11][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:53][C@H:51]([OH:52])[CH2:50][O:49][C:46]3[CH:47]=[CH:48][C:43]([OH:42])=[CH:44][CH:45]=3)=[CH:24][CH:23]=2)[CH2:13][CH2:14]1)=[O:19])[CH3:22]

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69987010HCID 69987010, compound

Product 1

HCID 10139202HCID 10139202, compoundYield 26.7%

Procedure

4-[4-(2-Aminoethyl)anilino]-N-ethyl-1-piperidinecarboxamide formate (0.336 g, 1.0 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.364 g, 0.90 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.17 g, 0.24 mmol).

Sources & evidence

ORD record
ord-88cb4b06b9414527849263fcefacf651
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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