HCID 69987111, compound → HCID 10143964, compound

HRID 1281498Notes

Reaction equation

HRID 1281498 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:31]=[CH:30][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.[SiH4].C([Si]([O:50][C:51]1[CH:56]=[CH:55][C:54]([O:57][CH2:58][CH:59]2[CH2:61][O:60]2)=[CH:53][CH:52]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][CH2:21][NH:20][C:18]([N:15]2[CH2:14][CH2:13][CH:12]([NH:11][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:61][C@H:59]([OH:60])[CH2:58][O:57][C:54]4[CH:55]=[CH:56][C:51]([OH:50])=[CH:52][CH:53]=4)=[CH:31][CH:30]=3)[CH2:17][CH2:16]2)=[O:19])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 69987111HCID 69987111, compoundHCID 131723495HCID 131723495, compound

Product 1

HCID 10143964HCID 10143964, compoundYield 18.8%

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(4-fluorophenethyl)-1-piperidinecarboxamide formate (0.875 g, 2.03 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane silane (0.740 g, 1.86 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.275 g, 0.35 mmol).

Sources & evidence

ORD record
ord-7f8d1ab307074077aba5594fb36175dd
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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