HRID1281502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COc1ccc(C2CCN(C(=O)N3CCC(Nc4ccc(CCNC[C@H](O)COc5ccc(O[Si](c6ccccc6)(c6ccccc6)C(C)(C)C)cc5)cc4)CC3)CC2)cc1OC1CCCC1

HCID86584581

未命名化合物

PRODUCTS

产物

反应SMILES：COc1ccc(C2CCN(C(=O)N3CCC(Nc4ccc(CCNC[C@H](O)COc5ccc(O)cc5)cc4)CC3)CC2)cc1OC1CCCC1

HCID10233652

未命名化合物

收率 68%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

{4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxy-propyl]amino}ethyl)anilino]-1-piperidinyl}{4-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-piperidinyl}methanone (0.168 g, 0.181 mmol) was reacted according to Procedure H to yield (eluant: 5:1 chloroform-methanol) the title compound (0.085 g, 0.123 mmol).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-4462f69b8fe040958dfb1fe0b36bcc04
来源数据集: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06451814B1
来源说明: uspto-grants-2002_09

反应SMILES

[Si]([O:18][C:19]1[CH:67]=[CH:66][C:22]([O:23][CH2:24][C@@H:25]([OH:65])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:64]=[CH:63][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([N:43]4[CH2:48][CH2:47][CH:46]([C:49]5[CH:54]=[CH:53][C:52]([O:55][CH3:56])=[C:51]([O:57][CH:58]6[CH2:62][CH2:61][CH2:60][CH2:59]6)[CH:50]=5)[CH2:45][CH2:44]4)=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH:58]1([O:57][C:51]2[CH:50]=[C:49]([CH:46]3[CH2:45][CH2:44][N:43]([C:41]([N:38]4[CH2:39][CH2:40][CH:35]([NH:34][C:33]5[CH:63]=[CH:64][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:65])[CH2:24][O:23][C:22]6[CH:66]=[CH:67][C:19]([OH:18])=[CH:20][CH:21]=6)=[CH:31][CH:32]=5)[CH2:36][CH2:37]4)=[O:42])[CH2:48][CH2:47]3)[CH:54]=[CH:53][C:52]=2[O:55][CH3:56])[CH2:62][CH2:61][CH2:60][CH2:59]1