HCID 69987576, compound → HCID 10120148, compound

HRID 1281508Notes

Reaction equation

HRID 1281508 reaction equation
[Si]([O:18][C:19]1[CH:56]=[CH:55][C:22]([O:23][CH2:24][C@@H:25]([OH:54])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:53]=[CH:52][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([NH:43][CH2:44][CH2:45][CH2:46][C:47]4[S:48][CH:49]=[CH:50][CH:51]=4)=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[S:48]1[CH:49]=[CH:50][CH:51]=[C:47]1[CH2:46][CH2:45][CH2:44][NH:43][C:41]([N:38]1[CH2:39][CH2:40][CH:35]([NH:34][C:33]2[CH:52]=[CH:53][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:54])[CH2:24][O:23][C:22]3[CH:55]=[CH:56][C:19]([OH:18])=[CH:20][CH:21]=3)=[CH:31][CH:32]=2)[CH2:36][CH2:37]1)=[O:42]

Participants

3

Reactant 1

HCID 69987576HCID 69987576, compound

Product 1

HCID 10120148HCID 10120148, compoundYield 41.3%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxy-propyl]amino}ethyl)anilino]-N-[3-(2-thienyl)propyl]-1-piperidinecarboxamide (0.182 g, 0.230 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol containing 1% ammonium hydroxide) to give the title compound (0.05 g, 0.095 mmol)

Sources & evidence

ORD record
ord-7b3fec1d2d694958895e4261a57f445a
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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