Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 69987167, compound

HRID 1281511Notes

Reaction equation

HRID 1281511 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:33]=[CH:32][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[C:23]=3[O:30][CH3:31])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.[C:34]([Si:38]([O:51][C:52]1[CH:57]=[CH:56][C:55]([O:58][CH2:59][CH:60]2[CH2:62][O:61]2)=[CH:54][CH:53]=1)([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)([CH3:37])([CH3:36])[CH3:35]>C(Cl)(Cl)Cl.CO>[Si:38]([O:51][C:52]1[CH:57]=[CH:56][C:55]([O:58][CH2:59][C@@H:60]([OH:61])[CH2:62][NH:4][CH2:5][CH2:6][C:7]2[CH:8]=[CH:9][C:10]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[C:23]=4[O:30][CH3:31])=[O:19])[CH2:14][CH2:13]3)=[CH:32][CH:33]=2)=[CH:54][CH:53]=1)([C:34]([CH3:35])([CH3:37])[CH3:36])([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[C:45]1[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69987324HCID 69987324, compound

Product 1

HCID 69987167HCID 69987167, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(2,3-dimethoxybenzyl)-1-piperidine-carboxamide formate (0.30 g, 0.64 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.238 g, 0.588 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.163 g, 0.20 mmol).

Sources & evidence

ORD record
ord-6f7d427eccd642069f3285146567550a
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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