Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10122343, compound

HRID 1281527Notes

Reaction equation

HRID 1281527 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:38]=[CH:37][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([N:28]4[CH:32]=[CH:31][CH:30]=[N:29]4)=[CH:24][C:23]=3[C:33]([F:36])([F:35])[F:34])=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:56][C:57]1[CH:62]=[CH:61][C:60]([O:63][CH2:64][CH:65]2[CH2:67][O:66]2)=[CH:59][CH:58]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[N:28]1([C:25]2[CH:26]=[CH:27][C:22]([CH2:21][NH:20][C:18]([N:15]3[CH2:14][CH2:13][CH:12]([NH:11][C:10]4[CH:37]=[CH:38][C:7]([CH2:6][CH2:5][NH:4][CH2:67][C@H:65]([OH:66])[CH2:64][O:63][C:60]5[CH:61]=[CH:62][C:57]([OH:56])=[CH:58][CH:59]=5)=[CH:8][CH:9]=4)[CH2:17][CH2:16]3)=[O:19])=[C:23]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH:32]=[CH:31][CH:30]=[N:29]1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69986893HCID 69986893, compound

Product 1

HCID 10122343HCID 10122343, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-Aminoethyl)anilino]-N-[4-(1H-pyrazol-1-yl)-2-(trifluoromethyl)benzyl]-1-piperidinecarboxamide formate (0.532 g, 1.0 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.404 g, 1.0 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.18 g, 0.20 mmol)

Sources & evidence

ORD record
ord-8277302478d840889261bb320db22e4e
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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