HCID 69987330, compound → HCID 10122343, compound

HRID 1281528Notes

Reaction equation

HRID 1281528 reaction equation
[Si]([O:18][C:19]1[CH:64]=[CH:63][C:22]([O:23][CH2:24][C@@H:25]([OH:62])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:61]=[CH:60][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([NH:43][CH2:44][C:45]4[CH:50]=[CH:49][C:48]([N:51]5[CH:55]=[CH:54][CH:53]=[N:52]5)=[CH:47][C:46]=4[C:56]([F:59])([F:58])[F:57])=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[N:51]1([C:48]2[CH:49]=[CH:50][C:45]([CH2:44][NH:43][C:41]([N:38]3[CH2:37][CH2:36][CH:35]([NH:34][C:33]4[CH:32]=[CH:31][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:62])[CH2:24][O:23][C:22]5[CH:21]=[CH:20][C:19]([OH:18])=[CH:64][CH:63]=5)=[CH:61][CH:60]=4)[CH2:40][CH2:39]3)=[O:42])=[C:46]([C:56]([F:58])([F:57])[F:59])[CH:47]=2)[CH:55]=[CH:54][CH:53]=[N:52]1

Participants

3

Reactant 1

HCID 69987330HCID 69987330, compound

Product 1

HCID 10122343HCID 10122343, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-[4-(1H-pyrazol-1-yl)-2-(trifluoromethyl)benzyl]-1-piperidinecarboxamide (0.18 g, 0.20 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol containing 1% ammonium hydroxide) to give the title compound (0.09 g, 0.13 mmol)

Sources & evidence

ORD record
ord-bf351fc84530459991e97730eb4b667c
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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