HCID 69986962, compound → HCID 10166207, compound

HRID 1281535Notes

Reaction equation

HRID 1281535 reaction equation
[Si]([O:18][C:19]1[CH:57]=[CH:56][C:22]([O:23][CH2:24][C@@H:25]([OH:55])[CH2:26][NH:27][CH2:28][CH2:29][O:30][C:31]2[CH:54]=[CH:53][C:34]([NH:35][CH:36]3[CH2:41][CH2:40][N:39]([C:42]([NH:44][CH2:45][C:46]4[CH:51]=[CH:50][C:49]([F:52])=[CH:48][CH:47]=4)=[O:43])[CH2:38][CH2:37]3)=[CH:33][CH:32]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[F:52][C:49]1[CH:48]=[CH:47][C:46]([CH2:45][NH:44][C:42]([N:39]2[CH2:38][CH2:37][CH:36]([NH:35][C:34]3[CH:33]=[CH:32][C:31]([O:30][CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:55])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:57][CH:56]=4)=[CH:54][CH:53]=3)[CH2:41][CH2:40]2)=[O:43])=[CH:51][CH:50]=1

Participants

3

Reactant 1

HCID 69986962HCID 69986962, compound

Product 1

HCID 10166207HCID 10166207, compoundYield 86.7%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethoxy)anilino]-N-(4-fluorobenzyl)-1-piperidinecarboxamide (0.125 g, 0.15 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol containing 1% ammonium hydroxide) to give the title compound (0.075 g, 0.13 mmol).

Sources & evidence

ORD record
ord-fe60883441de40dda93d67ece5fca427
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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