Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10230175, compound

HRID 1281538Notes

Reaction equation

HRID 1281538 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH:11]2[CH2:16][CH2:15][N:14]([C:17]([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:18])[CH2:13][CH2:12]2)=[CH:6][CH:5]=1.C([Si]([O:43][C:44]1[CH:49]=[CH:48][C:47]([O:50][CH2:51][CH:52]2[CH2:54][O:53]2)=[CH:46][CH:45]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[CH2:20]([NH:19][C:17]([N:14]1[CH2:15][CH2:16][CH:11]([S:10][C:7]2[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][NH:1][CH2:54][C@H:52]([OH:53])[CH2:51][O:50][C:47]3[CH:48]=[CH:49][C:44]([OH:43])=[CH:45][CH:46]=3)=[CH:9][CH:8]=2)[CH2:12][CH2:13]1)=[O:18])[CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173631HCID 18173631, compound

Product 1

HCID 10230175HCID 10230175, compoundYield 35.3%

Procedure

4-{[4-(2-Aminoethyl)phenyl]sulfanyl}-N-hexyl-1-piperidinecarboxamide (0.588 g, 1.617 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane (0.589 g, 1.455 mmol) according to Procedure G to give the title compound (eluant: 20/1 chloroform-methanol) (0.395 g, 0.514 mmol).

Sources & evidence

ORD record
ord-0ec1b1ccea274c299bb23eeef1f7f815
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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