HCID 70132728, compound → HCID 10121537, compound

HRID 1281544Notes

Reaction equation

HRID 1281544 reaction equation
[Si]([O:18][C:19]1[CH:58]=[CH:57][C:22]([O:23][CH2:24][C@@H:25]([OH:56])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([S:36]([CH:39]3[CH2:44][CH2:43][N:42]([C:45]([NH:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55])=[O:46])[CH2:41][CH2:40]3)(=[O:38])=[O:37])=[CH:32][CH:31]=2)=[CH:21][C:20]=1[CH3:59])(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH2:48]([NH:47][C:45]([N:42]1[CH2:43][CH2:44][CH:39]([S:36]([C:33]2[CH:32]=[CH:31][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:56])[CH2:24][O:23][C:22]3[CH:57]=[CH:58][C:19]([OH:18])=[C:20]([CH3:59])[CH:21]=3)=[CH:35][CH:34]=2)(=[O:38])=[O:37])[CH2:40][CH2:41]1)=[O:46])[CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH3:55]

Participants

3

Reactant 1

HCID 70132728HCID 70132728, compound

Product 1

HCID 10121537HCID 10121537, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-{[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}3-methyl-phenoxy)-2-hydroxypropyl]amino}ethyl)phenyl]sulfonyl}-N-octyl-1-piperidinecarboxamide (0.395 g, 0.520 mmol) was reacted according to Procedure H to give the title compound (eluant: 20/3(v/v) chloroform/methanol) (0.225 g, 0.373 mmol).

Sources & evidence

ORD record
ord-483bed12dfc64d228066bc4146ea52f2
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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