Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10167042, compound

HRID 1281554Notes

Reaction equation

HRID 1281554 reaction equation
C(O)=O.[NH2:4][CH2:5][CH2:6][C:7]1[CH:34]=[CH:33][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]3[CH:32]=[CH:31][C:24]([O:25][CH2:26][C:27]([O:29]C)=[O:28])=[CH:23][CH:22]=3)=[O:19])[CH2:14][CH2:13]2)=[CH:9][CH:8]=1.C([Si]([O:52][C:53]1[CH:58]=[CH:57][C:56]([O:59][CH2:60][CH:61]2[CH2:63][O:62]2)=[CH:55][CH:54]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[OH:62][C@H:61]([CH2:60][O:59][C:56]1[CH:57]=[CH:58][C:53]([OH:52])=[CH:54][CH:55]=1)[CH2:63][NH:4][CH2:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:11][CH:12]2[CH2:17][CH2:16][N:15]([C:18]([NH:20][C:21]3[CH:22]=[CH:23][C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:31][CH:32]=3)=[O:19])[CH2:14][CH2:13]2)=[CH:33][CH:34]=1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69986825HCID 69986825, compound

Product 1

HCID 10167042HCID 10167042, compoundYield 31%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Methyl 2-{4-[({4-[4-(2-aminoethyl)anilino]-1-piperidinyl}carbonyl)amino] phenoxy}acetate formate (0.48 g, 1.0 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.25 g, 0.62 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.16 g, 0.192 mmol).

Sources & evidence

ORD record
ord-9db45a1b303b48549e006744af7c37d2
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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