HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide → 4-(4-[2-[(2S)-3-(3-Acetylamino-phenoxy)-2-hydroxy-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic acid octylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide | HCID 18173662 | — |
| Reactant | N-{3-[(2S)oxiranylmethoxy]phenyl}acetamide | HCID 23381346 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | 4-(4-[2-[(2S)-3-(3-Acetylamino-phenoxy)-2-hydroxy-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic acid octylamide | HCID 69985801 | 28.9% |
Reaction Steps
4-[4-(2-Aminoethyl)anilino]-N-octyl-1-piperidinecarboxamide 0.421 g, 1.0 mmol) was reacted with N-{3-[(2S)oxiranylmethoxy]phenyl}acetamide (0.207 g, 1.0 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.168 g, 0.289 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06451814B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-d3568b86bd084a75aa1dc2c099c42b04 |
| Source note | uspto-grants-2002_09 |