HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform methanol → 4-(4-[2-[(2S)-3-(3-Fluoro-4-hydroxy-phenoxy)-2-hydroxy-propylamino]-ethyl]-phenylamino)-piperidine-1-carboxylic acid octylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform methanol | HCID 21584188 | — |
| Reactant | N-((4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy)-3-fluorophenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}carbonyl)-N'-octylurea | HCID 69987150 | — |
| Product | 4-(4-[2-[(2S)-3-(3-Fluoro-4-hydroxy-phenoxy)-2-hydroxy-propylamino]-ethyl]-phenylamino)-piperidine-1-carboxylic acid octylamide | HCID 10231259 | — |
Reaction Steps
N-({4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}-3-fluorophenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}carbonyl)-N′-octylurea (0.228 g, 0.271 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 2% triethylamine) to give the title compound (0.126 g, 0.223 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06451814B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-cff2772ddf8f4d8c903af0e37aedabf1 |
| Source note | uspto-grants-2002_09 |