HCID 69986991, compound → HCID 10185894, compound

HRID 1281572Notes

Reaction equation

HRID 1281572 reaction equation
[Si]([O:18][C:19]1[CH:54]=[CH:53][C:22]([O:23][CH2:24][C@@H:25]([OH:52])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:51]=[CH:50][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([NH:43][CH2:44][CH:45]4[CH2:49][CH2:48][CH2:47][CH2:46]4)=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[CH:45]1([CH2:44][NH:43][C:41]([N:38]2[CH2:39][CH2:40][CH:35]([NH:34][C:33]3[CH:50]=[CH:51][C:30]([CH2:29][CH2:28][NH:27][CH2:26][C@H:25]([OH:52])[CH2:24][O:23][C:22]4[CH:21]=[CH:20][C:19]([OH:18])=[CH:54][CH:53]=4)=[CH:31][CH:32]=3)[CH2:36][CH2:37]2)=[O:42])[CH2:49][CH2:48][CH2:47][CH2:46]1

Participants

3

Reactant 1

HCID 69986991HCID 69986991, compound

Product 1

HCID 10185894HCID 10185894, compoundYield 58.1%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-(cyclopentylmethyl)-1-piperidinecarboxamide (0.24 g, 0.32 mmol) was reacted according to Procedure H (eluant: 10:1 going to 5:1 chloroform-methanol containing 2% triethylamine) to give the title compound (0.095 g, 0.186 mmol).

Sources & evidence

ORD record
ord-b32b224485944f988db0409e02d15b59
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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