HRID1281573

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10512450

未命名化合物

结构：CCCCCCCCNC(=O)N1CCC(Nc2ccc(OCCN)cc2)CC1.O=CO

HCID69987684

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCNC(=O)N1CCC(Nc2ccc(OCCNC[C@H](O)COc3cccc4[nH]c(=O)[nH]c34)cc2)CC1

HCID10145302

未命名化合物

收率 19.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584188

Chloroform methanol

C2H5Cl3O

PROCEDURE

实验过程

4-[4-(2-Aminoethoxy)anilino]-N-octyl-1-piperidinecarboxamide formate (0.32 g, 0.733 mmol) was reacted with 4-[(2S)oxiranylmethoxy]-1,3-dihydro-2H-benzimidazol-2-one (0.151 g, 0.732 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.085 g, 0.142 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-532d0502335846fa9b11fd32fb3bec6f
来源数据集: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06451814B1
来源说明: uspto-grants-2002_09

反应 SMILES

C(O)=O.[NH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:31]=[CH:30][C:11]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([C:19]([NH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[O:20])[CH2:15][CH2:14]2)=[CH:10][CH:9]=1.[O:32]1[CH2:34][C@H:33]1[CH2:35][O:36][C:37]1[C:45]2[NH:44][C:43](=[O:46])[NH:42][C:41]=2[CH:40]=[CH:39][CH:38]=1>C(Cl)(Cl)Cl.CO>[CH2:22]([NH:21][C:19]([N:16]1[CH2:15][CH2:14][CH:13]([NH:12][C:11]2[CH:10]=[CH:9][C:8]([O:7][CH2:6][CH2:5][NH:4][CH2:34][C@H:33]([OH:32])[CH2:35][O:36][C:37]3[C:45]4[NH:44][C:43](=[O:46])[NH:42][C:41]=4[CH:40]=[CH:39][CH:38]=3)=[CH:31][CH:30]=2)[CH2:18][CH2:17]1)=[O:20])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]