Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 10232779, compound

HRID 1281576Notes

Reaction equation

HRID 1281576 reaction equation
C(O)=O.[CH3:4][N:5]([CH3:36])[C:6](=[O:35])[O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][NH:16][C:17]([N:19]2[CH2:24][CH2:23][CH:22]([NH:25][C:26]3[CH:31]=[CH:30][C:29]([CH2:32][CH2:33][NH2:34])=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)=[O:18])=[CH:10][CH:9]=1.C([Si]([O:54][C:55]1[CH:60]=[CH:59][C:58]([O:61][CH2:62][CH:63]2[CH2:65][O:64]2)=[CH:57][CH:56]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>C(Cl)(Cl)Cl.CO>[OH:64][C@H:63]([CH2:62][O:61][C:58]1[CH:59]=[CH:60][C:55]([OH:54])=[CH:56][CH:57]=1)[CH2:65][NH:34][CH2:33][CH2:32][C:29]1[CH:28]=[CH:27][C:26]([NH:25][CH:22]2[CH2:21][CH2:20][N:19]([C:17]([NH:16][CH2:15][CH2:14][C:11]3[CH:10]=[CH:9][C:8]([O:7][C:6](=[O:35])[N:5]([CH3:4])[CH3:36])=[CH:13][CH:12]=3)=[O:18])[CH2:24][CH2:23]2)=[CH:31][CH:30]=1

Participants

4

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 69987443HCID 69987443, compound

Product 1

HCID 10232779HCID 10232779, compoundYield 27.2%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-{2-[({4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}carbonyl)amino]ethyl}phenyl dimethylcarbamate formate (0.47 g, 0.94 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.40 g, 1.0 mmol) according to Procedure G (eluant: 20:1 chloroform-methanol) to give the title compound (0.22 g, 0.256 mmol).

Sources & evidence

ORD record
ord-80dd7bb90f874f30a5a652f2d8a87861
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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