HCID 69987081, compound → HCID 10232779, compound

HRID 1281577Notes

Reaction equation

HRID 1281577 reaction equation
[CH3:1][N:2]([CH3:62])[C:3](=[O:61])[O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][NH:13][C:14]([N:16]2[CH2:21][CH2:20][CH:19]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([CH2:29][CH2:30][NH:31][CH2:32][C@H:33]([OH:60])[CH2:34][O:35][C:36]4[CH:41]=[CH:40][C:39]([O:42][Si](C(C)(C)C)(C5C=CC=CC=5)C5C=CC=CC=5)=[CH:38][CH:37]=4)=[CH:25][CH:24]=3)[CH2:18][CH2:17]2)=[O:15])=[CH:7][CH:6]=1>C(Cl)(Cl)Cl.CO>[OH:60][C@H:33]([CH2:34][O:35][C:36]1[CH:37]=[CH:38][C:39]([OH:42])=[CH:40][CH:41]=1)[CH2:32][NH:31][CH2:30][CH2:29][C:26]1[CH:25]=[CH:24][C:23]([NH:22][CH:19]2[CH2:20][CH2:21][N:16]([C:14]([NH:13][CH2:12][CH2:11][C:8]3[CH:9]=[CH:10][C:5]([O:4][C:3](=[O:61])[N:2]([CH3:1])[CH3:62])=[CH:6][CH:7]=3)=[O:15])[CH2:17][CH2:18]2)=[CH:28][CH:27]=1

Participants

3

Reactant 1

HCID 69987081HCID 69987081, compound

Product 1

HCID 10232779HCID 10232779, compoundYield 56.6%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

4-{2-[({4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl)carbonyl)amino]ethyl}phenyl dimethylcarbamate (0.22 g, 0.256 mmol) was reacted according to Procedure H (eluant: 10:1 chloroform-methanol) to give the title compound (0.09 g, 0.145 mmol).

Sources & evidence

ORD record
ord-baaa1d2c29e94378b0f9e1380f027d12
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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