HCID 18173484, compound → HCID 69985896, compound

HRID 1281591Notes

Reaction equation

C(O[NH:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH:14]2[CH2:19][CH2:18][N:17]([C:20](=[O:48])[NH:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][Si](C(C)(C)C)(C4C=CC=CC=4)C4C=CC=CC=4)=[CH:25][C:24]=3[F:47])[CH2:16][CH2:15]2)=[CH:9][CH:8]=1)=O.C([Si]([O:66][C:67]1[CH:72]=[CH:71][CH:70]=[C:69]([O:73][CH2:74][CH:75]2[CH2:77][O:76]2)[CH:68]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:47][C:24]1[CH:25]=[C:26]([OH:29])[CH:27]=[CH:28][C:23]=1[CH2:22][NH:21][C:20]([N:17]1[CH2:16][CH2:15][CH:14]([NH:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][CH2:5][NH:4][CH2:77][C@H:75]([OH:76])[CH2:74][O:73][C:69]3[CH:70]=[CH:71][CH:72]=[C:67]([OH:66])[CH:68]=3)=[CH:12][CH:11]=2)[CH2:19][CH2:18]1)=[O:48]

Participants

Reactant 2

HCID 18173484HCID 18173484, compound

HCID 86584587HCID 86584587, compound

Product 1

HCID 69985896HCID 69985896, compoundYield 18.9%

Procedure

[2-(4-{1-[4-(tert-Butyl-dipheny-silanyloxy)-2-fluoro-benzylcarbamoyl]-piperidin-4-ylamino}-phenyl)-ethyl]-amino formate (1.05 g, 1.59 mmol) was reacted with tert-butyl-(3-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.642 g, 1.59 mmol) according to Procedure G to give the title compound (0.290 g, 0.3 mmol).

Sources & evidence

ORD record: ord-fc97b41d3a0740dca0e772f32c9bf3ed
Source dataset: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06451814B1

Reaction notes

Loading…