Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 70028828, compound

HRID 1281592Notes

Reaction equation

HRID 1281592 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:28]=[CH:27][C:7]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([NH:17][CH2:18][CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=3)=[O:16])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C([Si]([O:46][C:47]1[CH:52]=[CH:51][C:50]([O:53][CH2:54][CH:55]2[CH2:57][O:56]2)=[CH:49][CH:48]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[F:26][C:22]1[CH:21]=[C:20]([CH2:19][CH2:18][NH:17][C:15]([N:12]2[CH2:11][CH2:10][CH:9]([NH:8][C:7]3[CH:6]=[CH:5][C:4]([CH2:3][CH2:2][NH:1][CH2:57][C@H:55]([OH:56])[CH2:54][O:53][C:50]4[CH:51]=[CH:52][C:47]([OH:46])=[CH:48][CH:49]=4)=[CH:28][CH:27]=3)[CH2:14][CH2:13]2)=[O:16])[CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173526HCID 18173526, compound

Product 1

HCID 70028828HCID 70028828, compoundYield 41.4%

Procedure

4-[4-(2-Aminoethyl)anilino]-N-(3-fluorophenethyl)-1-piperidinecarboxamide (0.622 g, 1.62 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane 0.556 g, 1.40 mmol) according to Procedure G to give the title compound (eluant: 20:1 chloroform-methanol) (0.46 g, 0.580 mmol).

Sources & evidence

ORD record
ord-518310e81a024dff85025b2161c0810c
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

Loading…