HCID 70132332, compound → HCID 18173552, compound

HRID 1281597Notes

Reaction equation

HRID 1281597 reaction equation
[Si]([O:18][C:19]1[CH:58]=[CH:57][C:22]([O:23][CH2:24][C@@H:25]([OH:56])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:55]=[CH:54][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([C:43]4[NH:44][C:45]5[C:50]([CH:51]=4)=[CH:49][C:48]([O:52][CH3:53])=[CH:47][CH:46]=5)=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[OH:56][CH:25]([CH2:24][O:23][C:22]1[CH:21]=[CH:20][C:19]([OH:18])=[CH:58][CH:57]=1)[CH2:26][NH:27][CH2:28][CH2:29][C:30]1[CH:55]=[CH:54][C:33]([NH:34][CH:35]2[CH2:36][CH2:37][N:38]([C:41]([C:43]3[NH:44][C:45]4[C:50]([CH:51]=3)=[CH:49][C:48]([O:52][CH3:53])=[CH:47][CH:46]=4)=[O:42])[CH2:39][CH2:40]2)=[CH:32][CH:31]=1

Participants

3

Reactant 1

HCID 70132332HCID 70132332, compound

Product 1

HCID 18173552HCID 18173552, compoundYield 28.6%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

{4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}(5-methoxy-1H-indol-2-yl)methanone (0.128 g, 0.161 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound (0.026 g, 0.046 mmol).

Sources & evidence

ORD record
ord-8dfa44317a7d4edf9f05262279c7c853
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

Loading…