HCID 70132567, compound → HCID 69987744, compound

HRID 1281598Notes

Reaction equation

HRID 1281598 reaction equation
[Si]([O:18][C:19]1[CH:59]=[CH:58][C:22]([O:23][CH2:24][C@@H:25]([OH:57])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:56]=[CH:55][C:33]([NH:34][CH:35]3[CH2:40][CH2:39][N:38]([C:41]([C:43]4[NH:44][C:45]5[C:50]([CH:51]=4)=[CH:49][CH:48]=[CH:47][C:46]=5[N+:52]([O-:54])=[O:53])=[O:42])[CH2:37][CH2:36]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[OH:57][C@H:25]([CH2:24][O:23][C:22]1[CH:21]=[CH:20][C:19]([OH:18])=[CH:59][CH:58]=1)[CH2:26][NH:27][CH2:28][CH2:29][C:30]1[CH:31]=[CH:32][C:33]([NH:34][CH:35]2[CH2:36][CH2:37][N:38]([C:41]([C:43]3[NH:44][C:45]4[C:50]([CH:51]=3)=[CH:49][CH:48]=[CH:47][C:46]=4[N+:52]([O-:54])=[O:53])=[O:42])[CH2:39][CH2:40]2)=[CH:55][CH:56]=1

Participants

3

Reactant 1

HCID 70132567HCID 70132567, compound

Product 1

HCID 69987744HCID 69987744, compoundYield 70.1%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

{4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}(7-nitro-1H-indol-2-yl)methanone (0.117 g, 0.144 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound (0.058, 0.101 mmol).

Sources & evidence

ORD record
ord-00ab7ab2c4964fb39a99db149cc3f146
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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