HCID 69986966, compound → HCID 10167753, compound

HRID 1281600Notes

Reaction equation

HRID 1281600 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][NH:28][CH2:29][C@H:30]([OH:57])[CH2:31][O:32][C:33]4[CH:38]=[CH:37][C:36]([O:39][Si](C(C)(C)C)(C5C=CC=CC=5)C5C=CC=CC=5)=[CH:35][CH:34]=4)=[CH:22][CH:21]=3)[CH2:15][CH2:14]1)=[O:12])=[CH:5]2>C(Cl)(Cl)Cl.CO>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([N:13]1[CH2:14][CH2:15][CH:16]([NH:19][C:20]3[CH:21]=[CH:22][C:23]([CH2:26][CH2:27][NH:28][CH2:29][C@H:30]([OH:57])[CH2:31][O:32][C:33]4[CH:34]=[CH:35][C:36]([OH:39])=[CH:37][CH:38]=4)=[CH:24][CH:25]=3)[CH2:17][CH2:18]1)=[O:12])=[CH:5]2

Participants

3

Reactant 1

HCID 69986966HCID 69986966, compound

Product 1

HCID 10167753HCID 10167753, compoundYield 35.5%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

(5-Bromo-1H-indol-2-yl){4-[4-(2-{[(2S)-3-(4-{[tert-butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}methanone (0.119 g, 0.141 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound (0.031 g, 0.05 mmol).

Sources & evidence

ORD record
ord-47cde5b34a5945febbf1be4b7b85308c
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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