Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 69985389, compound

HRID 1281609Notes

Reaction equation

HRID 1281609 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:27]=[CH:26][C:7]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][N:18]=3)=[O:16])[CH2:11][CH2:10]2)=[CH:6][CH:5]=1.C([Si]([O:45][C:46]1[CH:51]=[CH:50][C:49]([O:52][CH2:53][CH:54]2[CH2:56][O:55]2)=[CH:48][CH:47]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[OH:55][C@H:54]([CH2:53][O:52][C:49]1[CH:50]=[CH:51][C:46]([OH:45])=[CH:47][CH:48]=1)[CH2:56][NH:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][N:18]=3)=[O:16])[CH2:11][CH2:10]2)=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18173814HCID 18173814, compound

Product 1

HCID 69985389HCID 69985389, compoundYield 32%

Procedure

{4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}(1H-indazol-3-yl)methanone (0.20 g, 0.55 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.222 g, 0.55 mmol) according to Procedure G to give the title compound (0.093 g, 0.176 mmol).

Sources & evidence

ORD record
ord-a7b7c24b7a7a4accb1d281c93c27eeda
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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