(2S)-2-[(4-fluorophenoxy)methyl]oxirane → N-[4-({4-[4-(2-{[(2S)-3-(2-allylphenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N-hexylurea

Participants

Role	Name	HCID	Charge
Reactant	(2S)-2-[(4-fluorophenoxy)methyl]oxirane	HCID 6932898	—
Reactant	N-[4-([4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N'-hexylurea formate	HCID 69985670	—
Product	N-[4-({4-[4-(2-{[(2S)-3-(2-allylphenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N-hexylurea	HCID 70133387	36.9%

Reaction Steps

N-[4-({4-[4-(2-Aminoethyl)anilino]-1-piperidinyl}sulfonyl)phenyl]-N′-hexylurea formate (0.172 g 0.314 mmol) was reacted (2S)-2-[(4-fluorophenoxy)methyl]oxirane (0.06 g, 0.315 mmol) according to Procedure G to give the title compound (0.04 g, 0.058 mmol).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06451814B1
Source dataset	uspto-grants-2002_09
ORD ID	ord-a5ea2c4512ce4399891cf519be0ffbf4
Source note	uspto-grants-2002_09