Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilane → HCID 69985554, compound

HRID 1281619Notes

Reaction equation

HRID 1281619 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:16][CH2:15][N:14]([S:17]([C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)(=[O:19])=[O:18])[CH2:13][CH2:12]2)=[CH:6][CH:5]=1.C([Si]([O:44][C:45]1[CH:50]=[CH:49][C:48]([O:51][CH2:52][CH:53]2[CH2:55][O:54]2)=[CH:47][CH:46]=1)(C1C=CC=CC=1)C1C=CC=CC=1)(C)(C)C>>[OH:54][C@@H:53]([CH2:55][NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]2[CH2:12][CH2:13][N:14]([S:17]([C:20]3[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=3)(=[O:19])=[O:18])[CH2:15][CH2:16]2)=[CH:6][CH:5]=1)[CH2:52][O:51][C:48]1[CH:49]=[CH:50][C:45]([OH:44])=[CH:46][CH:47]=1

Participants

3

Reactant 2

HCID 12045564Tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenylsilaneHCID 18174041HCID 18174041, compound

Product 1

HCID 69985554HCID 69985554, compoundYield 26.9%

Procedure

N-[4-(2-Aminoethyl)phenyl]-1-[(4-methylphenyl)sulfonyl]-4-piperidinamine (0.275 g, 0.65 mmol) was reacted with tert-butyl-(4-oxiranylmethoxy-phenoxy)-diphenyl-silane (0.251 g, 0.62 mmol) according to Procedure G to give the title compound (0.130 g, 0.167 mmol).

Sources & evidence

ORD record
ord-d974350254df40478b126accce8a168d
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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