Water → HCID 53855354, compound

Participants

Reaction Conditions

Reaction Steps

2,4-Dichloro-5-methyl-1,1,1-trifluorohex-2-ene (22.1 g) in dimethylformamide (100 ml) containing lithium chloride (5.0 g) is heated under a nitrogen atmosphere in an oil bath at 160° C. for 1.5 hours. The cooled mixture is added to water (1.5 l), extracted with dichloromethane and the extracts dried over anhydrous sodium sulphate and distilled to afford 2-chloro-5-methyl-1,1,1-trifluorohexa-2,4-diene (76%). The identity of the product was proved by comparison to 'Hnmr and infra-red spectra with those of authentic material.

Provenance & Evidence