HCID 69987104, compound → HCID 69985554, compound

HRID 1281620Notes

Reaction equation

HRID 1281620 reaction equation
[Si]([O:18][C:19]1[CH:55]=[CH:54][C:22]([O:23][CH2:24][C@@H:25]([OH:53])[CH2:26][NH:27][CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][C:33]([NH:36][CH:37]3[CH2:42][CH2:41][N:40]([S:43]([C:46]4[CH:51]=[CH:50][C:49]([CH3:52])=[CH:48][CH:47]=4)(=[O:45])=[O:44])[CH2:39][CH2:38]3)=[CH:32][CH:31]=2)=[CH:21][CH:20]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>C(Cl)(Cl)Cl.CO>[OH:53][C@@H:25]([CH2:26][NH:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([NH:36][CH:37]2[CH2:42][CH2:41][N:40]([S:43]([C:46]3[CH:47]=[CH:48][C:49]([CH3:52])=[CH:50][CH:51]=3)(=[O:45])=[O:44])[CH2:39][CH2:38]2)=[CH:32][CH:31]=1)[CH2:24][O:23][C:22]1[CH:54]=[CH:55][C:19]([OH:18])=[CH:20][CH:21]=1

Participants

3

Reactant 1

HCID 69987104HCID 69987104, compound

Product 1

HCID 69985554HCID 69985554, compoundYield 38.3%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

(2S)-1-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-3-{[4-({1-[(4-methylphenyl)sulfonyl]-4-piperidinyl}amino)phenethyl]amino}-2-propanol (0.130 g, 0.167 mmol) was reacted according to Procedure H (eluant: 5:1 chloroform-methanol) to give the title compound (0.035 g, 0.064 mmol).

Sources & evidence

ORD record
ord-01bb6fd1da34421e9ef0e40dadb7f5bc
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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