HCID 22713353, compound → HCID 22713410, compound

HRID 1281624Notes

Reaction equation

HRID 1281624 reaction equation
[N:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:25][CH2:24][C:19]4(OCC[O:20]4)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(O)=O>[N:1]1([S:7]([C:10]2[CH:11]=[CH:12][C:13]([N:16]3[CH2:17][CH2:18][C:19](=[O:20])[CH2:24][CH2:25]3)=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 1

HCID 22713353HCID 22713353, compound

Product 1

HCID 22713410HCID 22713410, compoundYield 79.5%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
60 °C

Procedure

8-[4-(1-Piperidinylsulfonyl)phenyl]-1,4-dioxa-8-azaspiro[4.5]decane (1.0 g, 2.73 mmol) was dissolved in formic acid and heated at 60° C. for 1 hour. The solvent was removed in vacuo and the residue crystallized from ethanol to give the title compound (0.70 g, 2.17 mmol).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue crystallized from ethanol

Sources & evidence

ORD record
ord-b945751be0c649b7b4a97bc501c2bf60
Source dataset
uspto-grants-2002_09
Patent number
US06451814B1

Reaction notes

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