Ammonia → HCID 23383155, compound

Participants

Reaction Steps

(±)-Trans-2-(2-bromo-5,6-dichloro-1H-benzimidazol-1-yl)cyclohexyl acetate (part c of this example, 500 mg, 1.23 mmol) was dissolved in methanol half-saturated with ammonia (at 0° C.) and the solution stirred at room temperature for 18 hours. Volatiles were evaporated and the residual solid recrystallized from methanol-water to give title compound as white crystals (350 mg, 78%), m.p. 186-188° C.; 1H-NMR (DMSO-d6, 200 MHz) δ: 8.23, 7.93 (both s, each 1, 2 aromatic CH), 4.99 (d, J=4.7 Hz, 1, OH), 4.34.1 (m, 2, OCH and NCH), 2.4-1.3 (m, 8, 4CH2).

Provenance & Evidence