反应详情

A solution of 16.3 g. of p-fluorobenzoylacetonitrile and 18.3 ml. of triethyl orthoacetate in 35 ml. of acetic anhydride is heated on a steam bath for 2.5 hours. The solvents are removed in vacuo and the residue is distilled at 165°-167° C./300μ. Upon cooling, this distillate solidifies and is recrystallized from methylene chloride/hexane to give the desired 2-(p-fluorobenzoyl)-3-ethoxycrotononitrile, m.p. 77°/89° C.

1. customThe solvents are removed in vacuo
2. distillationthe residue is distilled at 165°-167° C./300μ
3. temperatureUpon cooling
4. customthis distillate solidifies and is recrystallized from methylene chloride/hexane