Morpholine → HCID 9870644, compound

Participants

Reaction Conditions

Reaction Steps

Using an analogous procedure to that described in Example 3, a mixture of N-[3-(4diethylaminomethylbenzamido)-4-methylphenyl]-2-chloropyridine-4-carboxamide (0.5 g) and morpholine (5 ml) was stirred and heated to 110° C. for 16 hours. The resultant solution was cooled to ambient temperature and poured into water. The resultant solid was isolated, washed with diethyl ether and dried under vacuum at 40° C. There was thus obtained the title compound (0.021 g); NMR Spectrum: (DMSOd6) 1.0 (t, 6H), 2.2 (s, 3H), 2.44-2.49 (m, 4H), 3.42-3.57 (m. 4H), 3.6 (s, 2H), 3.65-3.63 (m, 4H), 7.08 (d, 1H), 7.2-7.25 (m, 2H), 7.45 (d, 2H), 7.58 (d, 1H), 7.79 (s, 1H), 7.92 (d, 2H), 8.26 (d, 1H), 9.83 (s, 1H), 10.28 (s, 1H); Mass Spectrum: M+H− 502.

Provenance & Evidence