N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide → N-{3-[3-(1-tert-butoxycarbonylpyrrolidin-3-yloxy)benzamido]-4-methylphenyl}-2-morpholinopyridine-4-carboxamide

Participants

Reaction Steps

Using an analogous procedure to that described in the first paragraph of Example 26, 3-(1-tert-butoxycarbonylpyrrolidin-3-yloxy)benzoic acid was reacted with N-(3-amino4-methylphenyl)-2-morpholinopyridine4-carboxamide to give N-{3-[3-(1-tert-butoxycarbonylpyrrolidin-3-yloxy)benzamido]-4-methylphenyl}-2-morpholinopyridine-4-carboxamide; NMR Spectrum: (DMSOd6) 1.42 (s, 9H), 2.15 (s, 2H), 2.22 (s, 3H), 3.44 (m, 3H), 3.55 (t, 4H), 3.6 (m, 1H), 3.77 (t, 4H), 5.18 (m, 1H), 7.13 (d, 1H), 7.21 (m, 1H), 7.37 (m, 2H), 7.5 (t, 1H), 7.56 (s, 1H), 7.61 (d, 2H), 7.81 (d, 1H), 8.3 (d, 1H), 9.9 (s, 1H), 10.31 (s, 1H); Mass Spectrum: M+H+ 602.

Provenance & Evidence