1-Methylpiperazine → N-[2-methyl-5(2-morpholinopyrid-4-ylcarbonylamino)phenyl]-3-(4methylpiperazin-1-yl)-2-nitrobenzamide

Participants

Reaction Steps

In an analogous procedure to that described in Example 15, N-[2-methyl-5-(2-morpholinopyrid-4ylcarbonylamino)phenyl]-3-chloro-2-nitrobenzamide was reacted with 1-methylpiperazine to give the title compound; NMR Spectrum: (DMSOd6) 2.84-2.89 (m, 4H), 2.92-3.08 (m, 4H), 3.58-3.61 (m, 4H), 3.81-3.84 (m, 4H), 6.95 (d, 1H), 7.09 (s, 1H), 7.10 (d, 1H), 7.41-7.44 (m, 2H), 7.53 (d, 1H), 7.76 (d, 1H), 7.96 (s, 1H), 8.04 (s, 1H), 8.3 (d, 1H); Mass Spectrum: M+H+ 560.

Provenance & Evidence