HRID1281729

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7993

3-(Dimethylamino)propylamine

C5H14N2

结构：Cc1ccc(NC(=O)c2ccnc(N3CCOCC3)c2)cc1NC(=O)c1cc(Cl)ccc1[N+](=O)[O-]

HCID22238142

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(NC(=O)c2ccnc(N3CCOCC3)c2)cc1NC(=O)c1cc(NCCCN(C)C)ccc1[N+](=O)[O-]

HCID18422107

未命名化合物

PROCEDURE

实验过程

In an analogous procedure to that described in Example 15, N-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)phenyl]-5-chloro-2-nitrobenzamide was reacted with 3-dimethylaminopropylamine to give the title compound; NMR Spectrum: (DMSOd6) 1.6-1.72 (m, 2H), 2.12 (s, 6H), 2.22-2.28 (m, 5H), 3.2-3.25 (m, 2H), 3.5-3.54 (m, 4H), 3.69-3.73 (m, 4H), 6.65-6.68 (m, 2H), 7.04 (d, 1H), 7.2 (d, 1H), 7.25 (d, 1H), 7.29 (t, 1H), 7.68 (d, 1H), 8.84 (s, 1H), 8.0 (d, 1H), 8.26 (d, 1H), 9.82 (s, 1H), 10.34 (s, 1H); Mass Spectrum: M+H+ 562.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7dbb71afd0e547a79dd6cbea326b5df8
来源数据集: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06455520B1
来源说明: uspto-grants-2002_09

反应 SMILES

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH:12]=2)=[O:10])=[CH:4][C:3]=1[NH:23][C:24](=[O:35])[C:25]1[CH:30]=[C:29](Cl)[CH:28]=[CH:27][C:26]=1[N+:32]([O-:34])=[O:33].[CH3:36][N:37]([CH3:42])[CH2:38][CH2:39][CH2:40][NH2:41]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[CH:12]=2)=[O:10])=[CH:4][C:3]=1[NH:23][C:24](=[O:35])[C:25]1[CH:30]=[C:29]([NH:41][CH2:40][CH2:39][CH2:38][N:37]([CH3:42])[CH3:36])[CH:28]=[CH:27][C:26]=1[N+:32]([O-:34])=[O:33]