2-Benzoyl-3-methoxycrotononitrile → 2-(p-Fluorobenzoyl)-3-methylaminocrotononitrile

HRID 128174Notes

Reaction equation

HRID 128174 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6](/[C:8](=[C:11](/OC)\[CH3:12])/[C:9]#[N:10])=[O:7])=[CH:4][CH:3]=1.C(/C(=C(/OC)\C)/[C:26]#[N:27])(=O)C1C=CC=CC=1>>[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6](/[C:8](=[C:11](/[NH:27][CH3:26])\[CH3:12])/[C:9]#[N:10])=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 234685002-Benzoyl-3-methoxycrotononitrileHCID 234685082-(p-Fluorobenzoyl)-3-methoxycrotononitrile

Product 1

HCID 234685142-(p-Fluorobenzoyl)-3-methylaminocrotononitrile

Procedure

The procedure of Example 15 is repeated substituting an equimolecular amount of 2-(p-fluorobenzoyl)-3-methoxycrotononitrile for the 2-benzoyl-3-methoxycrotononitrile employed in that example. There is thus obtained the title compound after purification by column chromatography.

Sources & evidence

ORD record
ord-e2c762fb55d44844a3f0cb2c15f651e3
Source dataset
uspto-grants-1981_03
Patent number
US04259256

Reaction notes

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