2-Benzoyl-3-methoxycrotononitrile → 2-(p-Fluorobenzoyl)-3-butylaminocrotononitrile

HRID 128175Notes

Reaction equation

HRID 128175 reaction equation
[C:1](/[C:9](=C(/OC)\C)/[C:10]#[N:11])(=O)[C:2]1C=CC=CC=1.[F:16][C:17]1[CH:31]=[CH:30][C:20]([C:21](/[C:23](=[C:26](/OC)\[CH3:27])/[C:24]#[N:25])=[O:22])=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:31]=[CH:30][C:20]([C:21](/[C:23](=[C:26](/[NH:11][CH2:10][CH2:9][CH2:1][CH3:2])\[CH3:27])/[C:24]#[N:25])=[O:22])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 234685002-Benzoyl-3-methoxycrotononitrileHCID 234685082-(p-Fluorobenzoyl)-3-methoxycrotononitrile

Product 1

HCID 705302592-(p-Fluorobenzoyl)-3-butylaminocrotononitrile

Procedure

By replacing the 2-benzoyl-3-methoxycrotononitrile employed in Example 16 with an equimolar amount of 2-(p-fluorobenzoyl)-3-methoxycrotononitrile, there is obtained the title compound in equally good yield.

Sources & evidence

ORD record
ord-83a42f384f074d86a4b2ba94196a82db
Source dataset
uspto-grants-1981_03
Patent number
US04259256

Reaction notes

Loading…