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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1281762Generated: October 26, 2026

2,4-Difluoronitrobenzene → Ethyl 2-(5-fluoro-2-nitroanilino)-6-methylbenzo[b]thiophene-3-carboxylate

https://huagongshe.com/reaction/1281762

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-DifluoronitrobenzeneHCID 67967—
ReactantEthyl 2-amino-6-methylbenzo[b]thiophene-3-carboxylateHCID 18422153—
SolventDimethyl SulfoxideHCID 679—
ProductEthyl 2-(5-fluoro-2-nitroanilino)-6-methylbenzo[b]thiophene-3-carboxylateHCID 1842218871.2%

Reaction Steps

In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-amino-6-methylbenzo[b]thiophene-3-carboxylate (4.5 g), 2,4-difluoronitrobenzene (3.1 g) and dimethyl sulfoxide, ethyl 2-(5-fluoro-2-nitroanilino)-6-methylbenzo[b]thiophene-3-carboxylate (5.1 g) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06455521B1
Source datasetuspto-grants-2002_09
ORD IDord-65f1eb6dbe7c4396a4c2363055e0efe6
Source noteuspto-grants-2002_09